Lupus dent in head17.11.2020
In the early stages of myeloma, some patients have no signs or symptoms of the disease. When symptoms are present, the most common ones are bone pain and fatigue. The letters stand for. Sometimes, you may have no symptoms. In this case, your doctor may first detect the disease as a result of a lab test or an X-ray taken for another reason. Signs and Symptoms. Print Glossary. Bone pain is the most common early symptom of myeloma.
Bones are constantly in a process of remodeling, maintaining a balance between bone destruction and formation. Myeloma causes an imbalance, with greater bone destruction and less new bone formation. This may result in bone thinning osteoporosis or holes in the bones lytic lesions.
Bones may break easily from activities as simple as coughing. The damage is most commonly found in the back or ribs, but it can occur in any bone. The pain is usually constant and made worse by movement. Bone lesions are present in about 80 percent of myeloma patients, most commonly in the spine and pelvis, but could affect any bone.
Bone lesions are not usually found in joints. Fatigue and weakness as a result of low red blood cell counts anemia.
Myeloma patients may fatigue more easily and feel weak. They may also have a pale complexion from anemia. Frequent infections due to a weakened immune system. A urinary tract, bronchial, lung, skin or other type of infection may be the first sign of the disease.
In addition, recurrent infections may complicate the course of the disease. Other signs and symptoms include: Damage to kidneys from high levels of antibodies proteins. The patient's urine may look foamy and the patient's legs may swell.
Numbness, tingling, burning or pain in the hands or feet caused by a condition called "peripheral neuropathy".
Symptoms of hyperviscosity syndrome are abnormal bleeding, headaches, chest pain, decreased alertness or shortness of breath. Live Chat. Follow us. Sign up for latest news This field is required Email address.Dent in skull or skull indentation, have you ever heard of this problem. It is a small depression in your skull.
It is not a normal variant in people. There is undoubtedly some or the other cause behind it. The causes may range from Nutritional deficiencies like vitamin A deficiency to severe infections like Meningitis. Let us explore them in detail in this article. Vitamin A is essential for having healthy skin, eyes, etc. But, too much of anything, even a good thing is harmful. Excess Vitamin A can leading to softening of the bones, including the skull leading to the formation of dent in skull or skull indentation.
Dent in skull can occur in kids when they are given more amount of Vitamin A than their daily requirement. First, let us understand the exact daily requirement of Vitamin A as per age group of the child. The symptoms of Vitamin A toxicity vary based on whether the toxicity is acute or chronic developed over several months. Let us explore symptoms of vitamin A toxicity in addition to dent in skull or skull indentation below:. Vitamin A toxicity can be diagnosed by checking the levels of Vitamin A in the blood.
It is treated by stopping the intake of vitamin A supplements as most often Vitamin A toxicity occurs due to excess intake of vitamin A supplements. It is a very rarely occurring disease of the bone.
In this disorder, there is a breakdown of the bone called osteolysis, and also the formation of abnormal new blood vessels. This disease can affect a single bone or multiple bones at the same time.
It can even involve the soft tissues over the bones. It occurs randomly in people.Skin conditions associated with lupus are fairly significant and a major marker of the disease. Of the eleven criteria set by the American College of Rheumatology for a diagnosis of lupus, four are skin-related. These include:. It is important to distinguish cutaneous lupus from systemic lupus erythematosus SLE. Cutaneous lupus refers to a form of the disease in which symptoms are restricted to those that affect the skin.
A patient may be diagnosed with cutaneous lupus, but that does not mean that he or she has SLE, which affects multiple parts of the body. Similarly, if a patient has SLE, it does not mean that he or she will necessarily have cutaneous lupus.
The prototypical example of acute cutaneous lupus is the malar rash. Subacute cutaneous lupus SCLE usually involves rashes on sun-exposed areas. This generally does not lead to scarring. Lastly, chronic cutaneous lupus can be further subdivided into a number of cutaneous findings including discoid, tumidus, profundus and chilblains. The hallmark condition of chronic cutaneous lupus is discoid lupus erythematosus DLE.
The malar rash, also known as the butterfly rash, extends from the cheeks across the nasal bridge. About half of patients with SLE develop this rash after ultraviolet light sun exposure. This may be difficult to distinguish from other conditions, such as rosacea. One distinguishing feature is that the malar rash usually does not involve the nasolabial fold the area on the face that runs from the corners of the upper lip to the nosewhile rosacea does.
The malar rash may develop months or years before the onset of lupus. They may also be polycyclic — that is, having the appearance of multiple rings coming together. Another characteristic finding of SCLE is that it is often found in sun-exposed areas. Lastly, patients with SCLE tend to exhibit a certain antibody profile. In addition to a positive antinuclear antibody ANAthey often exhibit anti-Ro and anti-La antibodies, which are important antibodies that can be seen in lupus. This can be important in pregnant women, because these antibodies can cross the placenta and affect the fetus.
In such cases, since the baby is at risk of neonatal lupus, the mother needs to be followed closely and additional treatment considered. In contrast to those diagnosed with SLE, patients with SCLE tend to experience fewer occurrences of cytopenia decreased numbers of blood cellsserositis inflammation of tissues lining the lungs, heart, and abdomenand positive ANA than patients with SLE.
Discoid Lupus Erythematosus DLE Lesions resulting from DLE have a scar-like center that is often surrounded by darker hyperpigmentation, primarily affecting the ears and scalp. These lesions can lead to hair loss, which can be permanent if the DLE is long-standing and loss of hair follicles occurs.
Prompt treatment is needed to prevent the scarring process. DLE affects the face as well, but does not typically affect areas below the neck. A skin biopsy is often required to confirm a diagnosis of cutaneous lupus.
Local anesthesia is administered and the physician then performs either a shave biopsy, which involves scraping the skin, or more commonly in lupus, a punch biopsy. Sunlight emits infrared, visible and ultraviolet light. The atmosphere filters out UVC. UVA does not get filtered out and can make it through windows or loosely woven clothing.
Rashes, Skin Care and Cutaneous Lupus: What You Should Know
Lee recommends that patients who spend a lot of time on the road driving get window tinting. There is no numerical scale to measure UVA at the moment, so Dr. Lee recommends looking for a sunscreen with at least an SPF of It is more important to reapply sunscreen every 2 hours on prolonged sun exposure ie gardening, walking about the city and use a thick amount than to use a sunscreen with a higher SPF.
He also emphasized that sunscreens should not be used as a means for extending duration of sun exposure. Sun protective hats and clothing can also help protect our skin from the sun.Kavita Pattani and Dr. The public doesn't hear about head and neck cancers as often as other cancers, possibly because they comprise about three percent of all forms of the disease.
But, the statistics are still shocking. The reality is, the risk for head and neck cancer is present in more Americans than you might think, particularly those of us who smoke and drink alcohol, the two biggest risk factors for head and neck cancers of the mouth, oropharynx, hypopharynx and larynx. In fact, at least 75 percent of head and neck cancers are caused by tobacco and alcohol use, according to the National Cancer Institute. However, environmental exposures may also play a role.
For instance, individuals working in some jobs in the construction, textile, ceramic, wood and metal industries could have an increased risk of paranasal sinus and nasal cavity cancer. Exposure to smoking and Epstein Barr Virus EBV is a risk factor for nasopharyngeal cancer, while certain other industrial exposures, like asbestos and synthetic fibers, have been linked to larynx cancer.
Human papillomavirus virus HPV is also a big risk factor for some kinds of head and neck cancers, specifically ones that involve the tonsils or base of the tongue. In fact, a large amount of oropharyngeal cancers, even reaching back 40 years, have actually been from HPV-positive tumors. Today in the United States, cancers caused by HPV infection are rising while cancers caused by smoking are falling. Additionally, sun exposure to the head and neck is a risk factor for skin cancers, and genetics can also play a role.
Extended periods of sun exposure, history of prior sunburns and cumulative lifetime exposure to the sun can result in various forms of skin cancers.
This is especially true for patients with fair skin, and those who may not use sun precautions. Patients with a family history of skin cancers such as melanoma are at increased risk of being predisposed to developing skin cancers, as well. And, a prior history of radiation exposure or metastatic disease from skin cancers can result in cancers of the salivary glands.
By definition, head and neck cancer arises in the head or neck region, impacting such sites as the nasal cavity, sinuses, oral cavity, salivary glands, throat and larynx or voice box. When patients get screened for cancer, it's usually because that individual felt pain in a certain area of the body. Unfortunately, there is little warning that someone may have a head or neck cancer, because often pain is not involved, which may lead to delay in care.
As surgical oncologists at Orlando Health, we've seen patients who think they simply have a sinus infection or allergic rhinitis that can be treated with antibiotics and medical management. Many times, however, they actually have sinus cancer. While something like a sinus infection is not always cancerous, there a few telltale signs that it may be more than just an infection, like pain or numbness in the teeth, decreased sense of smell, difficulty opening the mouth, a lump or sore inside the nose that does not heal, or pain and swelling in the face.
When these warning signs persist or worsen over several weeks, it's time to schedule a detailed physical exam with a doctor. Many of these symptoms can be caused by other noncancerous health conditions, but that's why it's so important to receive regular health and dental exams, especially if you routinely smoke or drink alcohol.
It's much easier to successfully treat sinus cancer when detected early. Given the rise in oropharynx cancers related to human papillomavirus HPVroutine examinations for early detection of this disease are more important than ever. We recommend routine checkups at least annually, but in addition to this, further evaluation is recommended with any worrisome or persistent findings. Understanding some of the different kinds of head and neck cancers and their symptoms is the first step in prevention.
Here are the main types everyone should be aware of:. Certain strains of HPV are associated with oropharynx cancers in the head and neck.
This type of infection can also lay dormant for many years and even decades prior to manifesting as a malignancy. A large majority of sexually active people will have some lifetime exposure to HPV.
Most tend to clear the virus from the system and only a small percentage of the population exposed will develop cancer. At this time a routine screening is not performed for the HPV virus for head and neck cancers.
The HPV is tested for its prognosticator value in those patients who develop oropharyngeal cancer.
Craniocervical Junction Disorders
The most common type of paranasal sinus and nasal cavity cancer is squamous cell carcinoma. This type of cancer forms in the squamous cells thin, flat cells lining the inside of the paranasal sinuses and the nasal cavity. Some risk factors can include environmental exposures such as exposure to wood or nickel dust or formaldehyde. Some of the most likely symptoms of this type of cancer are blocked sinuses that do not clear, or frequent sinuses that do not respond to treatment with antibiotics, bleeding through the nose, headaches, and pain in the upper teeth.
Many of these symptoms are not always cancerous, but it's still key to get regular examinations, especially for people who routinely smoke or drink alcohol.Note: Do consult your doctor for proper diagnosis and treatment of this condition. Use home remedies just as an adjunct treatment.
This disease occurs more commonly in women than men. The most common type of lupus is systemic lupus erythematosus SLE. The exact cause of this disease is not known, but experts believe it is usually a combination of genetics and environmental factors. Plus, chronic infections, stress, certain medications and even sunlight can trigger lupus. Thus, it can cause a variety of symptoms like fatigue, joint pain, swelling, muscle pain, low-grade fever, enlarged lymph nodes, chest pain, shortness of breath, fluid retention, headaches, photosensitivity and a butterfly-shaped rash across the cheeks and nose.
The symptoms tend to come and go. They can vary from person to person and may even change over time. Lupus can also cause life-threatening complications like cardiovascular disease and kidney problems in some people.
Diagnosing lupus is difficult because no single test can definitively diagnose it. Moreover, there is no cure. Treatment aims to control symptoms like pain and fatigue, reduce inflammation, prevent flare-ups and minimize organ damage. Most people with lupus can live a normal life. Early diagnosis and prompt treatment are key. Rheumatologists are specifically trained to treat this disease.
Plus, you can try some natural remedies to relieve symptoms and reduce the frequency of flare-ups. Most of the remedies can be used as needed. The active ingredient curcumin in turmeric has been found to be effective in the prevention as well as treatment of inflammatory autoimmune diseases including lupus.
According to a study published in the Journal of Renal Nutrition, turmeric can help reduce proteinuria, hematuria and systolic blood pressure in patients suffering from relapsing or refractory lupus nephritis. Note: Turmeric may not be suitable for those suffering from gallbladder problems. Plus, it may act like a blood-thinner. Ginger is another wonder spice useful in treating lupus with arthritic symptoms.It appears you have not yet Signed Up with our community.
I have noticed dents on my ankles, wrists the side of my knees. Does anyone here know or heard of such a thing? Thank you! I've been on C since ' I have the dents just above my knees on thighs. I think it's loss of muscle. I was afraid of scaring her. I don't have the disease but after many months of crying and worrying I'm okay. I've learned muscle loss can appear from all sorts of conditons.
Renee I'm glad you answered her. I also hate the way my legs look now. Between the injection marks and the loss of muscle tone, it is very disappointing. I have one "dent" in my thigh, and had no idea what it was or how it got there. This is insightful. I, too, have oh-so-lovely marks all over from betaseron shots.
Some are bruises that just never seem to heal, others are just wierd patches in the skin, like it's permanently damaged. I hate it! You currently have 0 posts. BB code is On. Smilies are On. Trackbacks are Off. Pingbacks are Off.
Rashes, Skin Care and Cutaneous Lupus: What You Should Know
Refbacks are Off. Forum Rules. Sign Up Today!Parry-Romberg syndrome is a rare neurocutaneous syndrome characterized by progressive shrinkage and degeneration of the tissues beneath the skin, usually on one side of the face. It is associated with neurological disorders such as trigeminal neuralgia, facial paresthesia, headache, and focal epilepsy. Concomitant occurrence of discoid lupus erythematosus DLE and morphea in the same skin lesion is exceptional, defined as overlap syndrome with two or more different connective tissue disease concurrently or consecutively.
A year-old female developed DLE on a long-standing lesion of scleroderma over left temporal area with characteristics histopathological changes. She was treated with oral antimalarials and steroids which halted the progress of the disease. Parry-Romberg syndrome PRS is a rare neurocutaneous syndrome characterized by progressive shrinkage and degeneration of the tissues beneath the skin, usually on one side of the face also called as progressive hemifacial atrophy.
Etiology is not well understood, although various hypotheses have been proposed. PRS is usually self-limiting. Immunosuppressants and corticosteroids are the treatment of choice in active disease state or if occurring concomitant with other autoimmune disorders.
The facial deformities may be corrected by reconstructive techniques involving grafting and other plastic surgical methods. Discoid lupus erythematosus DLE a relatively common condition is associated with interface dermatitis and hydropic degeneration of basal cells. It presents with coin shaped discoid lesions mainly on butterfly area of the face. Development of lesions in a linear distribution is unusual. A year-old-female working in the farm presented with a complaint of tightening and thickening of the skin over left cheek, forehead and scalp with loss of hairs and throbbing pain since almost 8 years.
She also complained of edema and pain over the right side of the face since 15 days. No history of cough, cold, dyspnea, chest pain, palpitations, nausea, vomiting, abdominal pain or joint pain was present.
No history of any seizure-like symptoms or cognitive impairment was given. Family history was unremarkable. Cutaneous examination showed well-defined linear atrophic plaque over left forehead, maxillary region that is, left cheek and frontal area of the scalp [ Figure 1 ]. Cicatricial alopecia with hyperpigmented plaques and mild scaling over left temporal region [ Figure 2 ]. Indurated and edematous plaque over right cheek and forehead [ Figure 1 ].
Buccal mucosa showed hyperpigmentation over both sides. The neurological examination was normal. Complete blood count, erythrocyte sedimentation rate, liver function test, renal function test and coagulation tests were normal.
Clinically patient was labeled as Parry-Romberg disease and a scalp biopsy was taken from the scaly lesion to confirm the diagnosis. The section showed in part changes of late sclerotic stage of morphea characterized by presence of thickened, closely packed and hypocellular collagen bundles in the reticular dermis. The papillary dermis also shows the presence of homogeneous collagen [ Figure 3 ].
Linear atrophic plaque over left forehead, maxillary region that is, left cheek and frontal area of the scalp with well-defined indurated and edematous plaque over right cheek and forehead. Cicatricial alopecia with hyperpigmented plaques and mild scaling over left temporal region.